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KMID : 0379520040200040315
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한국독성학회지
2004 Volume.20 No. 4 p.315 ~ p.320
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The Change of ATPase-positive Dendritic Cell and the Effect of Green Tea in Mouse Skin by Ultraviolet B Irradiation
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Kim Seong-Ho
Kim Se-Ra
Lee Hae-June
Lee Jin-Hee
Kim Yu-Jin
Kim Jong-Choon
Jo Sung-Kee
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Abstract
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In this study we assessed the influences of ultraviolet (UV) light B radiation on epidermal ATPase-positive dendritic cell (DC) and the effect of green tea treatment in ICR mouse. The extent of changes following 200 mJ/cm^2 (0.5 mW/sec) was studied at 0, 6, 12, 18, 24, 30 or 36 hours after exposure. SBCs were decreased by 6 hours after irradiation. There was tendency to decrease from 6 hours to 24 hours and had little further change from then to 36 hours after irradiation. The mice that received 0, 50, 100, 200, 300 or 400 mJ/cm^2 of UVB were examined 24 hours after irradiation. The DCs were decreased as the radiation dose increases from 100 to 400 mJ/cm^2. The frequency of UVB (200 mJ/cm^2)-induced DC decrease was reduced by treatment of green tea (i.p. and topical application, p<0.01).
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KEYWORD
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Ultraviolet B, ATPase-positive dendritic cell, ICR mouse, Green tea
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